Fertility Preservation Research Studies

Testicular Tissue Freezing

PRINCIPAL INVESTIGATOR: 

  • Kyle Orwig, PhD

PARTICIPANTS MUST BE:

  • Males older than 1 year old with two testes
  • Have a newly diagnosed or recurrent disease that requires chemotherapy or radiation treatment and puts them at high risk for infertility

DESCRIPTION:

The Fertility Preservation Program in Pittsburgh is conducting an experimental research study for young patients facing chemotherapy or radiation therapies that can threaten fertility. For these young patients who are not yet producing mature sperm, the Fertility Preservation Program is approved to freeze testicular tissue that might be used in the future to restore fertility when experimental techniques emerge from the research pipeline.

COMPENSATION:

The FPP program will cover the costs of surgery, tissue processing, tissue freezing, and the first year of frozen storage.


Ovarian Tissue Freezing

PRINCIPAL INVESTIGATOR:

  • Kyle Orwig, PhD

PARTICIPANTS MUST BE:

  • Females age 1 to 40 with two ovaries
  • Have a newly diagnosed or recurrent disease that requires chemotherapy or radiation treatment and puts them at high risk for infertility

DESCRIPTION:

The Fertility Preservation Program in Pittsburgh is conducting an experimental research study for young patients facing chemotherapy or radiation therapies that can threaten fertility. For these young patients who are not yet producing mature eggs, the Fertility Preservation Program is approved to freeze ovarian tissue that might be used in the future to restore fertility when experimental techniques emerge from the research pipeline.

COMPENSATION:

The FPP program will cover the costs of surgery, tissue processing, tissue freezing, and the first year of frozen storage

 


Genetic Effects of Chemotherapy on Sperm

PRINCIPAL INVESTIGATOR:

  • Kyle Orwig, PhD

INCLUSION CRITERIA for enrollment into the study are:

  • Adult males ages 18 through 50
  • Scheduled to undergo treatment with chemotherapy for a medical indication
  • Participants must not have any prior chemotherapy or radiation treatments
  • Participants with oligospermia (very low sperm counts) or azospermia (absent sperm count) will be excluded

DESCRIPTION:

The Fertility Preservation Program in Pittsburgh is conducting an experimental research study for adult male patients facing chemotherapy treatment. For these patients, semen will be collected prior to chemotherapy and after initiating chemotherapy. The majority of the sample collected before chemotherapy will be reserved for your clinical use in the future.

COMPENSATION:

Your insurance provider will be charged for the costs of semen analysis and collection of the sample taken before chemotherapy as this is standard of care. The FPP Program will cover the cost of semen cryopreservation and storage for the first year. You will not be charged any fees associated with semen samples collected after chemotherapy as these are research only samples

 

Fertility Assessment in Patients with Klinefelter Syndrome

Principal Investigators:

  • Kyle Orwig, PhD
  • Selma Witchel, MD

INCLUSION CRITERIA for enrollment into the study are:

  • males between the ages of 12 and 25
  • diagnosed with mosaic or non-mosaic Klinefelter’s Syndrome
  • having bilaterally descended testes

DESCRIPTION:

The Fertility Preservation Program in Pittsburgh is conducting an experimental research study for adolescent and young adult male patients with Klinefelter Syndrome. Patients will be counselled on the impact of Klinefelter on their future fertility. Urine samples will be collected and endocrine data will be collected from the medical record. Participants will have the opportunity to also pursue a semen analysis, but this is not mandatory for study participation.

COMPENSATION:

No direct payment will be made to the patient and/or his family for participating in this study. If a patient decides to pursue semen analysis as a result of the counselling he receives during study participation, the study will cover the cost for semen analysis at CFRE, as well as the first year of storage. A credit will be directly applied to the patient’s account.



Interested in participating in one of the fertility research studies above? Contact us for more information.