Fertility Preservation Research Studies

Testicular Tissue Freezing

PRINCIPAL INVESTIGATOR: 

  • Kyle Orwig, PhD

INCLUSION CRITERIA for enrollment into the study are:

  • Males older than 1 year old with two testes
  • Have a newly diagnosed or recurrent disease that requires chemotherapy or radiation treatment and puts them at high risk for infertility

DESCRIPTION:

The Fertility Preservation Program in Pittsburgh is conducting an experimental research study for young patients facing chemotherapy or radiation therapies that can threaten fertility. For these young patients who are not yet producing mature sperm, the Fertility Preservation Program is approved to freeze testicular tissue that might be used in the future to restore fertility when experimental techniques emerge from the research pipeline.

COMPENSATION:

The FPP program will cover the costs of surgery, tissue processing, tissue freezing, and the first year of frozen storage.


Ovarian Tissue Freezing

PRINCIPAL INVESTIGATOR:

  • Kyle Orwig, PhD

INCLUSION CRITERIA for enrollment into the study are:

  • Females age 1 to 40 with two ovaries
  • Have a newly diagnosed or recurrent disease that requires chemotherapy or radiation treatment and puts them at high risk for infertility

DESCRIPTION:

The Fertility Preservation Program in Pittsburgh is conducting an experimental research study for young patients facing chemotherapy or radiation therapies that can threaten fertility. For these young patients who are not yet producing mature eggs, the Fertility Preservation Program is approved to freeze ovarian tissue that might be used in the future to restore fertility when experimental techniques emerge from the research pipeline.

COMPENSATION:

The FPP program will cover the costs of surgery, tissue processing, tissue freezing, and the first year of frozen storage

 


Genetic Effects of Chemotherapy on Sperm

PRINCIPAL INVESTIGATOR:

  • Hanna Valli-Pulaski, PhD

INCLUSION CRITERIA for enrollment into the study are:

  • Adult males ages 18 through 50
  • Scheduled to undergo treatment with chemotherapy for a medical indication
  • Participants must not have any prior chemotherapy or radiation treatments
  • Participants with oligospermia (very low sperm counts) or azospermia (absent sperm count) will be excluded

DESCRIPTION:

The Fertility Preservation Program in Pittsburgh is conducting an experimental research study for adult male patients facing chemotherapy treatment. For these patients, semen will be collected prior to chemotherapy and after initiating chemotherapy. The majority of the sample collected before chemotherapy will be reserved for your clinical use in the future.

COMPENSATION:

Your insurance provider will be charged for the costs of semen analysis and collection of the sample taken before chemotherapy as this is standard of care. The FPP Program will cover the cost of semen cryopreservation and storage for the first year. You will not be charged any fees associated with semen samples collected after chemotherapy as these are research only samples

 

Testicular Tissue Freezing for Transgender Individuals

PRINCIPAL INVESTIGATOR:

  • Kyle Orwig, PhD

INCLUSION CRITERIA for enrollment into the study are:

  • Transgender females over the age of 9;
  • Who have been diagnosed with gender dysphoria;
  • Who are receiving gender affirming treatments or planning to start gender affirming treatments (hormone suppression or cross-sex hormones);
  • And who do not wish to delay or interrupt their gender affirming treatments to experience male puberty and produce sperm;
  • And who have a referral for a fertility preservation consultation from their primary care physician/team.

DESCRIPTION:

For many transgender females undergoing male puberty to produce sperm is undesired and even contra-indicated from a mental health standpoint. Testicular tissue cryopreservation is an alternative, experimental option to preserve fertility of transgender females who do not want to delay or interrupt their gender affirming therapies and/or undergo male puberty to produce sperm. Testicular tissues are banked in anticipation that those tissues can be matured in the future to produce sperm, either inside or outside the body.

COMPENSATION:

The FPP program will cover the costs of surgery, tissue processing, tissue freezing, and the first year of frozen storage.

Ovarian Tissue Transplantation

PRINCIPAL INVESTIGATOR:

  • Kyle Orwig, PhD

INCLUSION CRITERIA for enrollment into the study are:

  • Female patient between the ages of 18-45 years
  • Previously cryopreserved and stored cortical ovarian tissue available for autologous transplantation
  • Have ovarian insufficiency
  • Candidate for pregnancy
  • Written clearance for the procedure from the patient’s oncologist

DESCRIPTION:

The Fertility Preservation Program in Pittsburgh is conducting an experimental research study for female rendered infertile due to their treatment (chemotherapy, radiation, surgery) for a medical condition. Only patients who have previously cryopreserved ovarian tissue either here in Pittsburgh through our ovarian tissue cryopreservation protocol, or elsewhere in the world, are eligible for this study.

COMPENSATION:

The FPP program will cover the costs of surgery and tissue transplantation.

 

Retrieval of Sperm from Men with Azoospermia using Ultrasound-Guided Rete Testis Aspiration

PRINCIPAL INVESTIGATOR:

  • Kyle Orwig, PhD

INCLUSION CRITERIA for enrollment into the study are:

  • Be a male over the age of 18
  • Be scheduled to undergo testicular sperm extraction procedure at Magee-Womens Hospital of UPMC
  • Have 2 testicles

DESCRIPTION:

The Fertility Preservation Program in Pittsburgh is conducting an experimental research study to use ultrasound-guided rete testis flushing and aspiration technique to retrieve sperm from the testes of azoospermic men. For men with azoospermia, options to retrieve sperm are invasive and/or inefficient. Ultrasound-guided rete testis flushing/aspiration could represent a less invasive and more effective way to flush sperm from the testicular seminiferous tubules.

COMPENSATION:

The FPP program will cover the costs of the research portion of testicular sperm extraction.



Interested in participating in one of the fertility research studies above? Contact us for more information.